April 2025
Join us on April 16th at 5:00 PM for our meetup and discover how to leverage Graphics Processing Units (GPUs) for deep learning with biological data.
Our presentation, “Modeling Mutant Structures with Integrated Physics-Based and Deep Learning Methods,” will be given by Tandac Furkan Guclu, a postdoctoral researcher at Sabanci University, Türkiye.
Dr. Guclu’s research focuses on harnessing deep learning for rapid protein structure prediction and understanding the impacts of mutations. The talk will highlight how AlphaFold2, using diverse multiple sequence alignments (MSAs), can predict multiple protein conformations and reveal subtle structural changes. Additionally, the MuMi method combines systematic mutation introduction with energy minimization to rapidly generate conformations that recapitulate the dominant binding interactions observed in molecular dynamics (MD) simulations, enabling accurate prediction of protein fitness landscapes.
The presentation will include a hands-on demonstration showing how to set up MSAs, run AlphaFold2, and assess mutational effects.
Please note that this event will be held online.
Link for the meeting: https://meet.jit.si/monbugapril2025
You can also join with YouTube!
YouTube live link: https://youtube.com/live/5njyADGSmIA?feature=share
P.S. If you’re interested in presenting at a future event, feel free to contact us via Meetup or by email at info[AT]monbug.ca.