{"id":1940,"date":"2021-04-05T09:57:05","date_gmt":"2021-04-05T13:57:05","guid":{"rendered":"http:\/\/monbug.jplaverdure.ca\/?p=1940"},"modified":"2021-04-19T10:55:41","modified_gmt":"2021-04-19T14:55:41","slug":"meeting-davril","status":"publish","type":"post","link":"https:\/\/monbug.ca\/fr\/meeting-davril\/","title":{"rendered":"Meeting d&rsquo;avril"},"content":{"rendered":"<p>Joignez-vous \u00e0 nous virtuellement,<strong> mercredi le 14 avril \u00e0 16h30<\/strong> pour en apprendre davantage sur deux sujets bioinfo tr\u00e8s int\u00e9ressants. Vous aurez le plaisir d\u2019entendre :<\/p>\n<ul>\n<li><strong>Mathieu Bourgey<\/strong>, <em>Insights into single cell sequencing analysis <\/em>(en fran\u00e7ais)<\/li>\n<li><strong>Maria Virginia Ruiz Cuevas<\/strong>, <em>Most Non-canonical Proteins Uniquely Populate the Proteome or Immunopeptidome<\/em><\/li>\n<\/ul>\n<p><strong>Mathieu<\/strong>, responsable de la bio-informatique au Canadian Centre for Computational Genomics (C3G), fera un survol des aspects techniques li\u00e9s \u00e0 l&rsquo;analyse de donn\u00e9es de s\u00e9quen\u00e7age de cellules uniques (<em>single cell sequencing<\/em>).<\/p>\n<p><strong>Maria Virginia <\/strong>pr\u00e9sentera comment elle utilise des donn\u00e9es de s\u00e9quen\u00e7age pour identifier, caract\u00e9riser et quantifier les prot\u00e9ines non canoniques trouv\u00e9es dans les cellules canc\u00e9reuses. Ces prot\u00e9ines aux caract\u00e9ristiques distinctes pourraient jouer un r\u00f4le crucial dans l&rsquo;immunosurveillance des tumeurs.<\/p>\n<p>Nous allons utiliser jitsi pour la rencontre (voir le lien sur la page\u00a0<a href=\"https:\/\/www.meetup.com\/MonBUG\/events\/276986955\">Meetup<\/a>). \u00a0L\u2019\u00e9v\u00e9nement sera aussi retransmis sur YouTube Live : <a href=\"https:\/\/youtu.be\/Gqcut5NGpF0\">https:\/\/youtu.be\/Gqcut5NGpF0<\/a><\/p>\n<p>Vous pouvez vous enregistrer pour le meeting sur\u00a0<a href=\"https:\/\/www.meetup.com\/MonBUG\/events\/276986955\" target=\"_blank\" rel=\"noopener\">Meetup<\/a> ou en envoyant un courriel \u00e0 info@monbug.ca. \u00a0Et n\u2019oubliez pas de nous contacter via <a href=\"https:\/\/www.meetup.com\/MonBUG\" target=\"_blank\" rel=\"noopener\">Meetup<\/a> ou par courriel si vous aimeriez pr\u00e9senter lors d\u2019une future rencontre. \u00a0Nous sommes toujours \u00e0 la recherche de pr\u00e9sentateurs enthousiastes.<\/p>\n<p>* Voici le r\u00e9sum\u00e9 de la pr\u00e9sentation de Maria Virginia :<\/p>\n<p><strong>Most Non-canonical Proteins Uniquely Populate the Proteome or Immunopeptidome<\/strong>.\u00a0<a href=\"https:\/\/doi.org\/10.1016\/j.celrep.2021.108815\">\u00a0 <\/a>Significant evidence demonstrates the presence of unusual non-canonical proteins in cancer cells that appear to possess properties distinct from those of canonical proteins, making them important sources for the development of immunotherapies. Indeed, the immune system collects information about the health status of cells by reading protein fragments exposed on the cell surface. These fragments allow T cells to detect and eliminate cancer cells by reacting to the presence of unusual fragments. Because of their central role in cancer elimination, the identification of cancer-specific fragments is crucial for the design of vaccines that effectively stimulate the patient&rsquo;s own immune system to fight the disease. My research therefore aims to elucidate the hitherto elusive rules of biogenesis of non-canonical proteins in cancer cells. To do so, I develop and use computational strategies to study sequencing data to identify, characterize and quantify these unusual proteins. This will provide novel information on the cellular processes of protein synthesis and folding in normal and cancer cells, and thus allow us to identify with high confidence cancer-specific actionable fragments that can be tested in therapeutic vaccines. <a href=\"https:\/\/doi.org\/10.1016\/j.celrep.2021.108815\">10.1016\/j.celrep.2021.108815 <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Joignez-vous \u00e0 nous virtuellement, mercredi le 14 avril \u00e0 16h30 pour en apprendre davantage sur deux sujets bioinfo tr\u00e8s int\u00e9ressants. Vous aurez le plaisir d\u2019entendre : Mathieu Bourgey, Insights into single cell sequencing analysis (en fran\u00e7ais) Maria Virginia Ruiz Cuevas, Most Non-canonical Proteins Uniquely Populate the Proteome or Immunopeptidome Mathieu, responsable de la bio-informatique au [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":{"0":"post-1940","1":"post","2":"type-post","3":"status-publish","4":"format-standard","6":"category-page-accueil"},"_links":{"self":[{"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/posts\/1940","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/comments?post=1940"}],"version-history":[{"count":11,"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/posts\/1940\/revisions"}],"predecessor-version":[{"id":2051,"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/posts\/1940\/revisions\/2051"}],"wp:attachment":[{"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/media?parent=1940"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/categories?post=1940"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/tags?post=1940"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}