{"id":347,"date":"2011-01-18T11:43:52","date_gmt":"2011-01-18T16:43:52","guid":{"rendered":"http:\/\/www.monbug.org\/?p=347"},"modified":"2021-04-11T11:04:29","modified_gmt":"2021-04-11T15:04:29","slug":"jinbo-xu-2","status":"publish","type":"post","link":"https:\/\/monbug.ca\/fr\/jinbo-xu-2\/","title":{"rendered":"Jinbo Xu"},"content":{"rendered":"<p><a href=\"\/files\/meeting_posters\/Xu_2011_FR.pdf\">T\u00e9l\u00e9chargez l&rsquo;affiche de la rencontre<img decoding=\"async\" src=\"\/images\/pdf.gif\" data-lightbox=\"gallery\"  alt=\"PDF File\" \/><\/a><br \/>\n<strong>Titre de la Pr\u00e9sentation :<\/strong><br \/>\n<span style=\"color: #3399cc; font-weight: bold; font-size: 120%;\">Probabilistic Graphical Model for Protein Structure Prediction<\/span><\/p>\n<p><strong>Date \/ Heure \/ Emplacement:<\/strong><br \/>\nVendredi, 11 f\u00e9vrier 2011 &#8211; 16:00<br \/>\nSalle 232, \u00c9difice Leacock<br \/>\nMcGill University<br \/>\n855 Sherbrooke Ouest<\/p>\n<p><strong>Affiliation :<\/strong><br \/>\n<a href=\"http:\/\/www.ttic.edu\/\">Toyota Technological Institute, U. of Chicago<\/a><\/p>\n<p><strong>URL<\/strong><br \/>\n<a href=\"http:\/\/ttic.uchicago.edu\/~jinbo\/\">Jinbo Xu<\/a><\/p>\n<p style=\"text-align: justify;\"><strong>Abstract :<\/strong><br \/>\nIf we know the primary sequence of a protein, can we predict its three-dimensional structure by computational methods? This is one of the most important and difficult problems in computational molecular biology and has tremendous implications for protein functional study and drug discovery.<br \/>\nExisting computational methods for protein structure prediction can be broadly classified into two categories: template-based modeling (i.e., protein threading\/homology modeling) and template-free modeling (i.e., ab initio folding). Template-based modeling predicts structure of a protein using experimental structures in the Protein Data Bank (PDB) as templates while template-free modeling predicts protein structure without depending on a template.<br \/>\nThis talk will present new probabilistic graphical models for knowledge-based protein structure prediction. In particular, this talk will present a regression-tree-based Conditional Random Fields (CRF) method for template-based modeling and a Conditional Random Fields\/Conditional Neural Fields (CRF\/CNF) method for template-free modeling. Experimental results indicate that our template-based method performs extremely well, especially on hard template-based modeling targets and our template-free method is also very promising for mainly-alpha proteins.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>T\u00e9l\u00e9chargez l&rsquo;affiche de la rencontre Titre de la Pr\u00e9sentation : Probabilistic Graphical Model for Protein Structure Prediction Date \/ Heure \/ Emplacement: Vendredi, 11 f\u00e9vrier 2011 &#8211; 16:00 Salle 232, \u00c9difice Leacock McGill University 855 Sherbrooke Ouest Affiliation : Toyota Technological Institute, U. of Chicago URL Jinbo Xu Abstract : If we know the primary [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13,5],"tags":[],"class_list":{"0":"post-347","1":"post","2":"type-post","3":"status-publish","4":"format-standard","6":"category-activites-monbug","7":"category-page-accueil"},"_links":{"self":[{"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/posts\/347","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/comments?post=347"}],"version-history":[{"count":7,"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/posts\/347\/revisions"}],"predecessor-version":[{"id":765,"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/posts\/347\/revisions\/765"}],"wp:attachment":[{"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/media?parent=347"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/categories?post=347"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/tags?post=347"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}