{"id":561,"date":"2011-09-28T09:56:09","date_gmt":"2011-09-28T13:56:09","guid":{"rendered":"http:\/\/www.monbug.org\/?p=561"},"modified":"2021-04-11T11:04:28","modified_gmt":"2021-04-11T15:04:28","slug":"francois-major-2","status":"publish","type":"post","link":"https:\/\/monbug.ca\/fr\/francois-major-2\/","title":{"rendered":"Fran\u00e7ois Major"},"content":{"rendered":"

Titre de la Pr\u00e9sentation :<\/strong>
\nMicroRNAs and Stable Marriages<\/span><\/p>\n

Date \/ Heure \/ Emplacement:<\/strong>
\nVendredi, 21 octobre 2011 – 16:00
\nSalle 232, \u00c9difice Leacock
\nMcGill University
\n855 Sherbrooke Ouest<\/p>\n

Affiliation :<\/strong>
\nIRIC, DIRO — Universit\u00e9 de Montr\u00e9al<\/a><\/p>\n

URL<\/strong>
\nFran\u00e7ois Major<\/a><\/p>\n

Abstract :<\/strong>
\nProtein levels determine cell types and states. In eucaryotes, one of the mechanisms that control protein output is driven by microRNAs (miRNAs). Mature miRNAs are about 22-nucleotide long RNAs. They are loaded in and guide miRNA-induced silencing complexes (miRISCs) to bind to complementary sites in mRNAs. MiRISCs compete for mRNAs, and can work cooperatively to repress their translation in protein products. Therefore, the miRtargetome in a cell type or state, i.e. which miRNAs target which mRNAs, depends on the expressed miRNAs and mRNAs in it. In this presentation, I will describe an algorithm we developed to mimic miRISC competition and cooperation to predict miRtargetomes by cell types. I will also describe a series of biological consequences of miRNA-controlled protein output we derived by simulating the overexpression of single miRNAs in the K562 cell line. MiRNA levels vary in different cell types and states, including carcinomas. Understanding how miRNA levels affect protein output via miRtargetomes can thus explain how miRNA levels control cell differentiation and induce cancer development and progression.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Titre de la Pr\u00e9sentation : MicroRNAs and Stable Marriages Date \/ Heure \/ Emplacement: Vendredi, 21 octobre 2011 – 16:00 Salle 232, \u00c9difice Leacock McGill University 855 Sherbrooke Ouest Affiliation : IRIC, DIRO — Universit\u00e9 de Montr\u00e9al URL Fran\u00e7ois Major Abstract : Protein levels determine cell types and states. In eucaryotes, one of the mechanisms […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13,5],"tags":[],"class_list":{"0":"post-561","1":"post","2":"type-post","3":"status-publish","4":"format-standard","6":"category-activites-monbug","7":"category-page-accueil"},"_links":{"self":[{"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/posts\/561","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/comments?post=561"}],"version-history":[{"count":3,"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/posts\/561\/revisions"}],"predecessor-version":[{"id":757,"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/posts\/561\/revisions\/757"}],"wp:attachment":[{"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/media?parent=561"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/categories?post=561"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/monbug.ca\/fr\/wp-json\/wp\/v2\/tags?post=561"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}